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Background:Thrombotic event is one of mortality cause in SLE patients beside infection and disease activity.Thrombotic risk factors in SLE consist of antiphospholipid syndrome,accelerated atherosclerosis,and inflammation that will activate platelet and coagulation cascade.This study aimed to determine the correlation between MPV with D-dimer and Mex-SLEDAI as parameter of disease activity,and to find the cut-off value of MPV that correlate with D-dimer levels.Methods:This is a cross sectional study of SLE patients who do not consume antiplatelet/anticoagulant medication.All patients were assessed for Mex-SLEDAI score and blood sample for MPV and D-dimer was taken.Correlation between MPV with Mex-SLEDAI and D-dimer was analyzed using Pearsons analysis test.Results:Sixty three subjects(62 females,1 male),with median age 33(18-55)years old.Median duration of diagnosis is 3(0–25)years.Mucocutaneous,musculoskeletal and nephritis were found in 82.5%,79,4%and 50.7%subjects respectively.Mex-SLEDAI score ranging from 0–13,60.3%subjects are in remission(<2)and 27%in active disease(>5).Median of MPV 9.9(8.2–12.9)fL and median of D-dimer 365.51 ng/ml(97.58– 4938.10).There were no correlation between MPV with D-dimer(r=0.049,p=0.700),and MPV with Mex-SLEDAI(r=0.018,p=0.888).From ROC curve,MPV 10.3 fL had 48.1%sensitivity and 75%specificity in predicting D-dimer increment.Conclusion:There are no correlation between MPV with D-dimer level and MPV with Mex-SLEDAI score.Cut-off value for MPV to predict increased D-dimer level was 10.3 fL.