Glutathione sensitive nanocomplexes based on hyaluronic acid/graphene oxide conjugates for targeted

来源 :Fourth Symposium on Innovative Polymers for Controlled Deliv | 被引量 : 0次 | 上传用户：samhsa

【摘要】

：

【作者】

：

Huiyun Wen Xing Liu Yishu He Chunli Song Weiming Xue

【机构】

：

School of Chemical Engineering,Northwest University,Xi 'an 710069,China

【出处】

：

Fourth Symposium on Innovative Polymers for Controlled Deliv

【发表日期】

：

2016年11期

【关键词】

：

graphene oxide hyaluronic acid redox sensitive targeted drug delivery

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

　　There has been an ever increasing interest in designing glutathione (GSH) sensitive drug delivery systems (DDS) to improve therapeutic efficiency as well as minimize drug side effects.Those GSH sensitive DDS engineered with disulfide bond linked sheddable shells are particularly interesting,which maintain stable within blood circulation (GSH 2-10 μM) but allow fast release of therapeutic drugs by cleavage of disulfide bonds triggered by high GSH level (2-10 mM) inside cancer cells[1].

其他文献

Efficient intracellular protein and peptide delivery by a surface-engineered dendrimer

Efficient delivery of proteins and peptides into cells remains a major challenge due to the presence of multiple barriers in intracellular protein delivery.In recent years,functional nanoparticles hav

会议

protein deliverypeptide deliverydendrimerpolymerrational design

A light-responsive polymer for the co-delivery of anticancer drugs and therapeutic genes

Nanoscale stimuli-responsive systems for gene and drug delivery have recently received tremendous attention[1].The systems that sensitive to a specific trigger may provide a specific release of the pa

会议

dendrimercoumarinlight-responsiveco-deliveryanticancer drug

A novel strategy to prepare 2D YBO3∶Ce3+-Yb3+ nanosheets with enhanced near-infrared (NIR) emission

Over the past decades,much effort has been devoted to design of novel sustained/controlled drug delivery systems.However,as commonly used fluorescent components,organic dyes usually suffer from rapid

会议

2D materialsYBO3∶Ce3+-Yb3+near-infrared (NIR)luminescence

Engineered nanogel with superior tissue affinity and cell targeting toward orthotopic bladder cancer

Adjuvant chemotherapy is the most important strategy to prevent the recurrence of bladder cancer after surgery[1].However,the low permeability effect and short residence time of intravesical drug make

会议

polycationsdisulfide bondpolypeptide nanogeltissue affinitycontrolled drug d

Multifunctional binary-drug loaded liposomes for targeting cancer therapy

Nanocarriers have shown great potential for targeting delivery of therapeutic molecules to tumors[1].Compared to small molecule anti-cancer drugs,nanomedicines with the features of tumor targeting,lon

会议

drug combinationactive-targetingliposomesnanocarrierscancer treatment

Genetically engineered yeast spores as chitosan microspheres for intracellular delivery of immunosti

Synthetic oligodeoxynucleotides (ODNs) containing unmethylated CpG motifs activate innate and adaptive immune responses by activation of Toll-like receptor 9 (TLR 9)[1,2].CpG ODNs show strong potentia

会议

CpG oligodeoxynucleotidessaccharomyces cerevisiae sporeschitosancytokine secr

Fabrication of the supramolecular complexes of matrine by host-guest binding and electrostatic inter

Matrine (MAT) is widely used in the treatment of ulcerative colitis[1].However,it cannot reach an effective concentration in the colorectal area,leading to low availability and severe toxic side-effec

会议

sulfobutyl ether β-cyclodextrinmatrineelectrostatic interactioncontrolled del

Reduction-responsive disulfide cross-linked dextrin nanogel mediated Bcl-2 siRNA delivery for antica

Smart nanogels consisting of cross-linked network can be responsive to bio-stimuli,such as pH and redox.Dextrin has been widely used for drug delivery systems because of its biodegradability and noncy

会议

dextrin nanogelreduction-responsivedisulfide cross-linkedlysosomal escapesiR

Dual-stimulus-responsive crosslinking chitosan as a gene vector

Stimulus-responsive gene vectors,that release gene in response to endosomal pH or cytoplasmic glutathione (GSH) have attracted increasing interests in tumor therapy[1,2].Developing gene-delivery syste

会议

Chitosanstimulus-responsivegene vectorsacylhydrazonedisulfide

Composite scaffold with gradient content of simvastatin for enhanced large cranial defect repair

Bioactive scaffolds-based tissue engineering is a promising strategy for repairing cranial defects[1].How to impart the scaffolds with appropriate physiochemical properties and osteoinductivity remain

会议

electrospunsimvastatinbioactive composite scaffoldgradient inducingbone rege

Glutathione sensitive nanocomplexes based on hyaluronic acid/graphene oxide conjugates for targeted

与本文相关的学术论文