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  5. Identification of PEAR1 single-nucleotide polymorphisms and their influences on the variation in Pra

Identification of PEAR1 single-nucleotide polymorphisms and their influences on the variation in Pra

来源 :The 12th Meeting of the Asia Pacific Federation of Pharmacol | 被引量 : 0次 | 上传用户：janmey2007
【摘 要】
：
Aim: The platelet responses to antiplatelet drugs are highly variable.However,the associated mechanisms are poorly defined.The present study aimed to investigate PEAR1 genetic polymorphisms and pharma
【作 者】
：
Qian XIANG Yi-min CUI Xia ZHAO Nan ZHAO 
【机 构】
：
Department of Pharmacy,Base for Clinical Trial,Peking University First Hospital,Beijing 100034,China
【出 处】
：
The 12th Meeting of the Asia Pacific Federation of Pharmacol
【发表日期】
：
2013年4期
【关键词】
：
PEAR1 Han Chinese subjects prasugrel genetic polymorphism pharmacodynamics 
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Aim: The platelet responses to antiplatelet drugs are highly variable.However,the associated mechanisms are poorly defined.The present study aimed to investigate PEAR1 genetic polymorphisms and pharmacogenetic variability in the pharmacodynamics of prasugrel, a new oral antiplatelet agent, in 36 healthy Han Chinese subjects.
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