Gene mutation detection is playing an important role in clinical disease diagnosis.Now, gene mutation always detected by traditional methods as polyacrylamide gel basis on polymerase chain reaction.But these methods could not satisfy the fast clinical gene mutation detection.Capillary electrophoresis (CE) is a new pattern segregation analysis technology, which incorporate electrophoresis with chromatograph.The CE technique has advantages of rapidity, sensitivity, less samples and broad application range, so it has became one of important way to separate and detect DNA fragment.