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Objective Some studies have shown that Lysine Methyltransferase 2C(KMT2C),a relative gene of histone methyltransferase family,is an important coding gene of epigenetic modification.KMT2C mutates frequently in multiple human cancers and is crucial to the occurrence or growth of numerous cancers.The relationship between KMT2C mutation and clinicopathological characteristics in breast cancer patients is still unclear.We explored the KMT2C gene mutation in different populations and the differences between the mutants and the non-mutants in clinicopathological characteristics,and provided a certain clinical basis for the genetic diagnosis of breast cancer and the individualized and accurate treatment.