Braid-reinforced (BR) cellulose acetate (CA) hollow fiber membrane which prepared through the concentric circles coating and dry-wet spinning method is modified by incorporating graphene oxide (GO) into the separation layer.The performance of the GO modified CA membranes, which varies with the size of the GO nanosheet and the GO/CA ratio in the coating solution, is characterized in terms of mechanical properties, permeate flux, and morphology observations by a scanning electron microscopy (SEM).SEM images show that the BR hollow fiber membranes have a favorable interfacial bonding state between the separation layer and the braid;the wider finger-like structure and thinner skin layer appear in the separation layer by the addition of GOs.The maximum pure water flux (PWF) of GO modified CA membranes are obtained as the GO sheet size is 30-50 μm and the GO/CA ratio reaches to 1 wt%.Introduction of 1 wt% GOs (especially with larger sheet size) brings about increased permeate flux and flux recovery during the protein solution filtration, which indicates that the anti-fouling performance of the BR membranes are improved.The tensile strength of the BR membranes is about 30 MPa which mainly depends on the braids.The incorporation of GO endows the BR CA hollow fiber membranes with a higher bursting strength.