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  5. Determination of lapachol by liquid chromatographic-mass spectrometry and the application to pharmac

Determination of lapachol by liquid chromatographic-mass spectrometry and the application to pharmac

来源 :The 12th Meeting of the Asia Pacific Federation of Pharmacol | 被引量 : 0次 | 上传用户：jinxiangjinshu
【摘 要】
：
Aim: To study the quantification methods and pharmacokinetic application of lapachol.Methods: A sensitive and specific high-performance liquid chromatography-tandem mass spectrometry method (LC/ESI/MS
【作 者】
：
Lu BAI Yin HAN Xiao-rong LI Yu-hang Li Pin-xiang XU Xiao-hui LIU Ming XUE 
【机 构】
：
Department of Pharmacology, School of Basic Medical Sciences, Capital Medical University, Beijing 10
【出 处】
：
The 12th Meeting of the Asia Pacific Federation of Pharmacol
【发表日期】
：
2013年4期
【关键词】
：
lapachol determination pharmacokinetics LC-ESI-MSn 
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Aim: To study the quantification methods and pharmacokinetic application of lapachol.Methods: A sensitive and specific high-performance liquid chromatography-tandem mass spectrometry method (LC/ESI/MS) was developed and validated for quantification of the bioactive naphthoquinone lapachol in rat plasma after intragastric administration.
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