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In most research works ofbiomolecular chip and sensor, electric field are used to drive DNA molecules transporting along the micro/nano-fluidic channel and pore.In order to accurately and flexibly induce and control the DNA molecules moving in these micro-/nano-scale fluidic channels, the current change rule of buffer caused by applied bias is one of the fundamental issues.In this report,the high-precision micro voltage-current system (E-Corder401, EDAQ.