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  5. B2 induces sedative and hypnotic effects via activating the hypothalamic ventrolateral preoptic neur

B2 induces sedative and hypnotic effects via activating the hypothalamic ventrolateral preoptic neur

来源 :The 12th Meeting of the Asia Pacific Federation of Pharmacol | 被引量 : 0次 | 上传用户：wqg
【摘 要】
：
Aim: B2 is a novel derivative of N6-(4-hydroxybenzyl) adenine riboside originally isolated from Gastrodia elata Blume.The ventrolateral preoptic nucleus (VLPO) is a group of neurons in the hypothalamu
【作 者】
：
Yuan SHI Jing-wen DONG Rui-xia KANG Jian-jun ZHANG 
【机 构】
：
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia
【出 处】
：
The 12th Meeting of the Asia Pacific Federation of Pharmacol
【发表日期】
：
2013年4期
【关键词】
：
ventrolateral preoptic area insomnia hypnotics sleep y-aminobutyric acid 
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Aim: B2 is a novel derivative of N6-(4-hydroxybenzyl) adenine riboside originally isolated from Gastrodia elata Blume.The ventrolateral preoptic nucleus (VLPO) is a group of neurons in the hypothalamus that release the inhibitory neurotransmitter γ-aminobutyric acid (GABA) during sleep.It plays an important role in sleepwake regulation.In this study, we examined the sedative and hypnotic effects of B2 and its influence on the VLPO in mice.
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