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Background: The underlyingbrain basis of nonclinical depressive symptoms(nCDSs)is largely unknown.Recently,the seedbasedfunctional connectivity(FC)approachforanalyzingresting-state fMRI(rs-fMRI)datahas been increasingly usedto explorethe neural basis of depressive disorders.Other than common seed-based FC method using an a priori seed region,we conducted FC analysis based on regions with altered spontaneous activity revealed by the fractional amplitude of low-frequency fluctuations(fALFF)approach.The aimof the presentstudy wasto provide novel insight inthe underlying mechanism of nCDSs in college students.Methodology/PrincipalFindings: A total number of 1105 college students were recruited to participant in a survey for assessing depressive symptoms.Subsequently,17individuals with nCDSs and 20 healthy controls(HCs)were enrolled to performMRstudies.Alternations of fALFF wereidentifiedin the right superior parietal lobule(SPL)and left lingual gyrus,both ofwhich were used as ROIs for further FC analysis.With right SPL,compare with HCs,subjects with nCDSs showed reduced FCs in the bilateraldorsal lateral prefrontal cortex(DLPFC),leftinferior frontal gurus(IFG),left premotor cortex(PMC),DMN network [i.e.,bilateral precuneus,posterior cingulate cortex(PCC),right supramarginalgyrus(SMG),right parahippocampal gyrus(PHG),bilateral inferior temporal gurus(ITG)]and left cerebellum posterior lobe(CPL).In addition,increased FCswereobserved between the left lingual gyrusand right fusiform gyrus as well as in the left precuneus.Conclusion/Significance:Our results indicatethe abnormalitiesofspontaneous activity in the right SPL and left lingual gyrus and their corresponding dysfunction of the brain circuits might be related to the pathophysiology of nCDSs.