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Objective: Patent foramen ovale provides a bypass through which cancer cells can go direct to the systemic circulation.Cancer patients with patent foramen ovale may have high risk of distant metastasis.Because lung cancer cells can go into systemic circulation by pulmonary capillary with the least physical barrier,it is not clear if the patent foramen ovale can increase metastasis in lung cancer.Therefore,we design the clinical research to explore the relationship between distant metastasis ofnon-samll cell lung cancer and patent foramen ovale.