【摘 要】
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目的 p38MAPK,a mitogen-activated protein kinase,plays a negative regulating role in the pathogenesis of acute respiratorydistress syndrome(ARDS)induced by lipopolysaccharide(LPS).A p38MAPK inhibitor has
【机 构】
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The Fifth People's Hospital of Shanghai Fudan University
【出 处】
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2016中华医学会呼吸病学年会暨第十七次全国呼吸病学学术会议
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目的 p38MAPK,a mitogen-activated protein kinase,plays a negative regulating role in the pathogenesis of acute respiratorydistress syndrome(ARDS)induced by lipopolysaccharide(LPS).A p38MAPK inhibitor has previously been shown to alleviateinflammatory reaction.We recently proposed that the balance of T helper17(Th17)and Treg cells regulated in this inflammatoryconditions.In the present study,we investigated in vivo the effect of Th17/Treg balance on p38MAPK inhibitor relieved mildARDS induced by LPS方法 KM mice received SB203580(50,100 mg/kg)intraperitoneally 1 h prior to the intratracheal instillation of lipopolysaccharide(LPS)challenge.We analyzed regulatory and Th17-associated cytokines,such as IL-17,IL-10,IL-23,IL-6,TGF-β in BALF by ELISA.The mRNA express of FOXP3 and RORrt by real-time PCR,The cells number of Th17 and Treg by FACS at Lung bronchial lymphnodes.IL-6 and TNF-a in serum.We also investigated histopathological conditions in Lung tissue.
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