Objectives To compare the non-ionic(godadiamide,Gd-DTPA-BMA)and ionic(gadopentetate dimeglumine,Gd-DTPA)Gadolinium based contrast agents(GBCA)in the quantitative evaluation of C6 glioma with DCE-MR by using Patlak method.Materials and Methods C6 glioma model was established in 12 Wistar rats,and MR scan was performed 6 days after tumor were implanted.DCE-MRI was performed on A 3.0T MR scanner,with 7-inch handmade circular coil.Sequence included precontrast T1map and dynamic contrast enhanced T1WI after a bolus injection(0.2 ml/s)of GBCA at 0.4 mmol/kg.Each rat received two DCE-MRI scans with 24 hours apart.The first was with Gd-DTPA-BMA and the second was with Gd-DTPA.Image data were processed by using Patlak model.Both Ktrans and FV map were generated.Tumors were manually segmented on all 3D Ktrans and FV maps.Pixel counts and mean values were recorded for paired t test.Three radiolologists independently performed tumor segmentation and value calculation.The agreements from different observers were subjective to intra-class correlation coefficient(ICC).Results Readers demonstrated the pixel counts of tumor in Ktrans map with Gd-DTPA-BMA and Gd-DTPA were 155±90,158±86,153±79 vs 71±12,77±40,66±35(P<0.001,all readers),and the average Ktrans values were 0.064±0.056/min,0.069±0.054/min,0.060±0.043/min vs 0.038±0.029/min,0.043±0.076,0.036±0.025,(P>0.05,all readers),respectively.The pixel counts of tumor in FV map with Gd-DTPA-BMA and Gd-DTPA were 125±55,128±55,132±52 vs 113±57 118±52,123±48(P>0.05,all readers)and the average Vp values were 0.089±0.034,0.078±0.032,0.091±0.028 vs 0.094±0.028,0.086±0.026 0.089±0.026(P>0.05,all readers),respectively.All readers showed good correlations in ICC test.Conclusions Significant more pixel counts of glioma were found with Gd-DTPA-BMA,and the average Ktrans value with Gd-DTPA-BMA were larger.