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Objective：The aim of the present study was to examine the expression status of inducible nitric oxide synthase(iNOS) in osteosarcoma of the jaw,and its relationshipswith tumor angiogenesis and clinicopathological characteristics．
Conclusion：Osteosarcoma of the jaw was associated with overexpression of iNOS，which correlated with tumor microvessel densitv．iNOS expression furthermore correlated with the size，pathological grade，and clinical’stage of the osteosarcoma,and also with clinicopathological characteristics such as primary occurrence or recurrence of tumors．There was no correlation with metastasis．iNOS may promote tumor angiogenesis in osteosarcoma of the jaw,and so may represent an important target in anti-tumor therapy．