Co3-xFexO4 ferrite (CF), which structure transforms from normal spinel into inverse spinel as x increases that leads to the appearance of new active sites in the samples, has conceived considerable attention for its potential applications in enzymatic mimetics, anode material for lithium ion batteries, and an important catalyst for various oxidation and reduction reactions.Here, a facile method is proposed for the synthesis of three-dimensional (3D) flower-like Co3-xFexO4 ferrite (CF) hollow spheres.