Systemic lupus erythematosus(SLE)is a chronic,heterogeneous autoimmune disease short of effective therapeutic agents.A multitude of studies of SLE in the last decade have accentuated a central role of
The transporter MshA is a kind of multidrug resistance ATP-binding cassette transporter that can transport lipid A,lipopoly saccharides,and some amphipathic: drugs from the cytoplasmic to the periplas
The introduction of INF inhibitors has revolutionized the treatment of some chronic inflammatory diseases,e.g.,rheumatoid arthritis and Crohns disease.However,immunogenics ty is one of the important m
Motivation: One of the most promising applications of biosynthetic methods is to produce chemical products of high value from the ready-made chemicals.To explore the biosynthetic potentials of a chemi
Interfcrence wich dynamic equilibrium of microtubulc-tubulin has provcn to be a uscful tactics in the clinic.Based on investigation into the structure-activity relationship(SAR)studies of tuhulin poly
Histone deacetylases(HDACs)are an important class of drug targets for the treatment of cancers,neurodegenerative diseases,and other types of diseases.Virtual screening(VS)has become fairly effective a
Uncoupling protein 1(UCP1)plays an important role in promoting brown adipose tissue formation and strengthening function of increasing energy expenditure.Thus,activation of UCP1 has become an appealin
As a type Ⅱ or Ⅲ transmembrane glycoprotein,human CD38 is ubiquitously expressed in all mammalian tissues.CD38 is a multi-functional enzyme and a member of the ADP-ribosyl cyclase family,and it cataly
plekstrin homology(PH)domains share low sequence identities But extremely conserved structures.They have been found in many proteins for cellular signal-dependent membrane targeting by binding inosito