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Background: Diabetic retinopathy (DR) is a major complication of diabetes and vascular endothelial growth factor (VEGF) plays a critical role in the development and progression of DR.Breviscapine (Bre) is a mixture of flavonoid glycosides extracted from Chinese herb Erigerin Breviscapus (Vant.) Hand-Mazz, scutellarin (Scu) is the primary active ingredient of breviscapine.Scu is extensively used for the treatment of micro-blood vessels diseases but has poor water solubility.