【摘 要】
：
With the rapid development of nanotechnology, nanomaterials are widely used and developed in modem industry and life.Silica nanoparticles (SiNPs) are among nanomaterials with the highest production an
【机 构】
：
Key Laboratory of Modern Toxicology of Shenzhen, Medical Key Laboratory of Health Toxicology and Lab
【出 处】
：
中国毒理学会生化与分子毒理专业委员会学术会议暨环境内分泌干扰物的毒理学研究新技术新方法研讨会
论文部分内容阅读
With the rapid development of nanotechnology, nanomaterials are widely used and developed in modem industry and life.Silica nanoparticles (SiNPs) are among nanomaterials with the highest production and have been formulated for cellular and non-viral gene delivery in the central nerve system.However, the potential negative effects of SiNPs on the brain remain poorly understood.In this study, we demonstrated by transmission electron microcopy (TEM) that SiNPs entered the brain and were widely distributed in olfactory bulb, hippocampus and cortex of the Sprague-Dawley (SD) rats treated with 15-nm SiNPs at a dose of 2.5 mg/kg·bw by intranasal instillation (once every other day, totally 8 weeks).
其他文献
目的:探讨邻苯二甲酸二(2-乙基己)酯(DEHP)对雄性大鼠睾丸中激素相关基因表达水平的影响,为研究DEHP生殖毒性提供科学依据.方法:40只5周龄雄性SPF级SD大鼠,随机分为对照组(玉米油)、DEHP低剂量组(100mg/kg)、DEHP中剂量组(500mg/kg)和DEHP高剂量组(1500mg/kg),每组10只,每天灌胃染毒1次,每周5次,连续染毒6周.于末次染毒24 h后处死动物,实时
内分泌干扰特征农药主要通过4种作用模式危害干扰人类和动物的内分泌系统.内分泌干扰类特征农药风险评估可以根据危害识别,危害表征,暴露评估和风险表征的流程开展.世界上各国家对于内分泌干扰类特性农药的法规监管以欧盟发展最为迅速和全面,欧盟不同化学品管理部门的法规框架,包括植物保护产品注册法规,生物杀灭剂法规和REACH法规,对内分泌干扰类特性农药的法规注册要求均有阐述,但各法框架规间的数据要求和管理决策
本文首先介绍了miRNA的功能及机制研究方法，其次介绍了miRNA在肿瘤诊断、治疗、预后的临床上的应用，对miRNA能调控基因表达和细胞进程的发现，为人们理解肿瘤发生的机制提供了新的思路。
本文首先介绍了邻苯二甲酸酯类塑化剂的理化特性，其次介绍了塑化剂的来源与接触机会，然后介绍了塑化剂在人体的吸收、分布、代谢与排泄，分析了急性、慢性塑化剂的一般毒性，重点分析了雄性、雌性、胚胎生殖毒性，介绍了致突变作用、致癌作用及环境内分泌干扰物作用，分析了部分食品中塑化剂含量，指出塑化剂引起生殖毒性的有关基因组学、蛋白质组学、基因调控、信号转导等方面是今后的努力方向，值得深入探讨。
Objective To investigate the effects of silica nanoparticles in expression profiles of membrane proteins in HaCaT cells.Methods We utilized a subcellular fractionation method to extract membrane fract
目的：多溴联苯醚(PBDEs)是一种重要的溴化阻燃剂,目前已在多种环境介质、生物和人体中发现它的存在,而其具有强亲脂性、难降解性和蓄积性使其对环境以及人类的健康造成潜在的威胁.PBDEs已被证明具有多种毒性,为人们所关注的主要是其发育神经毒性和内分泌干扰毒性,其中,内分泌干扰毒性对生物体的生殖系统影响尤为严重.虽然已有相关的研究报道PBDEs对生殖系统造成不良影响,如精子数量减少,青春期延长、生殖
目的：长链非编码RNA (long noncoding RNA,kncRNA)在基因转录调控,调节转录后RNA加工翻译、DNA甲基化和染色质结构等方面具有重要功能,作为基因组非编码RNA(noncoding RNA,ncRNA)中数量最丰富的种类,已经证实在大脑中有高水平的表达,但其性质和生物学功能并没有被详细研究.为了探讨在铅吸收、铅中毒过程中lncRNA的表达变化及其相应的机制,我们利用神经细
Objective To detect the alterations of the telomerase activity and the expression for genes response to oxidative stress related with cellular senescence during the replicative senescence and hydrogen
Cadmium (Cd) has been considered the environmental contaminant because of the multiple adverse health effects.Unlike other heavy metals such as Lead (Pb) and Mercury(Hg), the placenta is less affected
Hydroquinone (HQ), a metabolite of benzene, is known to be associated with acute myelogenous leukemia (AML) risk;however, its carcinogenic mechanism remains unclear.We now report that HQ induces DNA d