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The DREB (dehydration responsive elementbinding)-type transcription factors (TFs) regulate the expression of many stress inducible genes by binding to the DRE/CRT cis-element present in the promoter region of these genes.Overexpression of DREB-type TFs enhances abiotic stress tolerance in transgenic plant.SiDREB2A (Setaria italica dehydration responsive element binding protein 2A) is a new DREB-type TF that was cloned from Setaria italica.