【摘 要】
：
Cardiac ischemia and reperfusion(I/R) injury remains a challenge for clinicians.Ginsenoside Rb1(Rb1) has been reported to have the ability to attenuate I/R injury,but its effect on energy metabolism d
【机 构】
：
Department of Integration of Chinese and Western Medicine,School of Basic Medical Sciences,Peking Un
【出 处】
：
2016年第一届中国微循环周(中国病理生理学会微循环专业委员会全体会议、世界中医药学会联合会气血专业委员会全体会议、中国
论文部分内容阅读
Cardiac ischemia and reperfusion(I/R) injury remains a challenge for clinicians.Ginsenoside Rb1(Rb1) has been reported to have the ability to attenuate I/R injury,but its effect on energy metabolism during cardiac I/R and the underlying mechanism remain unknown.In this study,we detected the effect of Rb1 on rat myocardial blood flow,myocardial infarct size,cardiac function,velocity of venule red blood cell,myocardial structure and apoptosis,energy metabolism and change in RhoA signaling pathway during cardiac I/R injury.In addition,the binding affinity of RhoA to Rb1 was detected using surface plasmon resonance(SPR).
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