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The bending problem of a four clamped rectangular plate with in-plane variable stiffness is studied by using the method of superposition.By choosing a simply supported plate as a basic system,the plate with four clamped edges is regarded as the superposition of one four simply supported plate under the transverse load and two four simply supported plate under pure bending.The bending problem of a four clamped rectangular plate with in-plane variable stiffness under the transverse load is solved.And the influence of in-plane variable stiffness on the deflection and bending moment is studied through numerical examples.Analytical solution presented herein may be helpful for the design of rectangular plates with in-plane variable stiffness.