【摘 要】
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Serum albumin is the most abundant protein in blood plasma.The binding of drugs with serum albumin plays an important role in the study of the bioavailability,efficacy,transport and designing of the d
【机 构】
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Department of chemistry,Islamic Azad University,Shahrekord Branch,Young researchers club
【出 处】
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第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会
论文部分内容阅读
Serum albumin is the most abundant protein in blood plasma.The binding of drugs with serum albumin plays an important role in the study of the bioavailability,efficacy,transport and designing of the drugs.Two typical non-steroidal anti-inflammatory drugs are ibuprofen,and aspirin which used commonly as analgesic drug in clinical medicine and sometimes are co-administered.Docking is conducted by a procedure involving multiple conformer shape-matching alignment of a molecule to a cavity followed by energy minimization on both the molecule and the protein residues at the binding region.In this work,we have taken the Human Serum Albumin receptor and the commercially available drugs pain reliever.
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