论文部分内容阅读
A novel nanoscaled gene delivery system was designed to reduce carrier-associated cytotoxicity and to enhance the gene transfection activity of PEI (Scheme 1).The biodegradable polycation, poly(ethylene glycol)-block-(poly(L-glutarnic acid)-graft-polyethylenimine) (PEG-b-(PG-g-PEI)), was simply synthesized by the ammonolysis of Poly(ethylene glycol)-block-poly(γ-benzyl L-glutamate) with 600 Da polyethylenimine (Scheme 2).