Microbiota improve immune defense against hepadnavirus infection through promoting hepatic γδT-17 ce

来源 :中国免疫学会第九届全国免疫学学术大会 | 被引量 : 0次 | 上传用户:tianbentb
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Backgroud: Though microbiota products derived from gut obviously shape the liver immune microenvironment, few direct evidences and mechanisms were reported.Aim: To study the role and the mechanism of microbiota in shaping liver antiviral immune response.Methods: Adenovirus was used as a typical hepadnavirus which can induce a series of immune responses mediated by many different kinds of immune cells in liver.Mice treated with antibiotics (referred as Atb mice) were used as Microbiota depleted mice.FACS assay was used to analyze the immune cell composition and cytokines production.
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