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RNA interference(RNAi)is emerging as one of promising strategies for tumor therapy,especially for inhibiting tumor metastasis [1].However,an efficient and safety non-virus delivery system for clinical siRNA therapy is still a major challenges.The clinical applications of cationic non-viral vectors are limited because of their low transfection efficiency,especially in the serum containing mediums and real in vivo conditions.The difficulty of lysosome escape and nonspecific adsorption of serum proteins are considered the main reasons.In this talk,Id like to introduce several recent approaches developed by our group to overcome these barriers for siRNA delivery.