Mesenchymal stem cells (MSCs,also known as mesenchymal stromal cells) are known to be the component of tumor microenvironment.MSCs are multipotent stromal cells that can differentiate into a variety of cell types,including osteocytes,chondrocytes,adipocytes,epithelial and endothelial.Stem cells in niches or transplanted into injured tissues constantly encounter hypoxic stress.Areas with very low or even zero oxygen pressure exist in solid tumors.