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Background The feasibility, safety and efficacy between TR and TF approach for coronary interventional treatment have been compared in some complicated situations including AMI, unprotected left main coronary artery disease.However, in terms of triple vessel disease intervention, there is still no comparison regarding procedural and long-termoutcomes between TR and TF approach.The present study sought to compare outcomes between transradial (TR) and tranfemoral (TF) intervention treatment in triple vessel coronary artery disease.