2. 您的位置
3. 首页
4. 会议论文
5. A research on the mechanism of TH-302 in hypoxic environment and TH-302 combined with radiation appl

A research on the mechanism of TH-302 in hypoxic environment and TH-302 combined with radiation appl

来源 :第十三届全国胃癌学术会议 | 被引量 : 0次 | 上传用户：focus2316a

【摘 要】

：

Objective Tumors often contain hypoxic regions resistant to chemo-and radiotherapy.TH-302 is an investigational hypoxia-activated prodrug that selectively releases the DNA cross-linker bromo-isophosph

【作 者】

：

Ran Hu Yun Deng Wang Yang Menglong Zhou Guichao Li Zhen Zhang 

【机 构】

：

Department of Radiation Oncology,Fudan University Shanghai Cancer Center,270 Dongan Road,Shanghai,20

【出 处】

：

第十三届全国胃癌学术会议

【发表日期】

：

2018年3期

【关键词】

：

TH-302 radiation hypoxia tumor apoptosis HIF-1 

下载到本地 , 更方便阅读

下载此文 赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

　　Objective Tumors often contain hypoxic regions resistant to chemo-and radiotherapy.TH-302 is an investigational hypoxia-activated prodrug that selectively releases the DNA cross-linker bromo-isophosphoramide mustard under hypoxic conditions.

其他文献

Validation of the 8th edition of AJCC/UICC pTNM classification of gastric cancer:a retrospective stu

Objective To evaluate the prognostic ability of the 8th edition pTNM classification for gastric cancer compared with the 7th edition.The shortage of new classification system was present and proposed

会议

8th editionAJCC/UICCpTNM classificationgastric cancer

Overexpression of BRD4 contributes to poor prognosis in gastric cancer and promotes tumor progressio

Objective Gastric cancer(GC)is the common cause of cancer-related malignancy worldwide of digestive tract.Nowadays,radical operation for GC enhanced by standardized lymphadenectomy remains the current

会议

BRD4gastric cancerMRK/ERK pathwayprognosis

HOXA11表达水平与胃癌患者预后的相关性研究

目的 胃癌是一种异质性的疾病，虽然已经有许多风险指标可以预测术后胃癌患者的预后，但是为了满足胃癌精准治疗的需要，仍需探索新的预后评判指标。因此，我们评判了同源盒序列基因A11(HOXA11)对于胃癌患者的预后价值。

会议

HOXA11预后胃癌列线图

A novel oral camptothecin analog,gimatecan,exhibits superior antitumor efficacy than irinotecan towa

Objective Esophageal squamous cell carcinoma cancer(ESCC)is one of the most frequently diagnosed and deadly malignancy with few standard therapeutic options,it is urgent to develop new therapeutic str

会议

esophageal squamous cell carcinomatopoisomerase Ⅰ inhibitorDNA damagecell cyc

High CLDN7 Expression is an Independent Predictor of Favorable Survival in Patients with Gastric Can

Objective Gastric cancer(GC)is one of the most common malignances in the world.During the past decades,survival of patients with GC have improved significantly due to early diagnosis and advances in t

会议

CLDN7claudingastric canceroverall survivalTCGA

Apolipoprotein C1(APOC1)increases tumor growth and invasion via activating MAPK signaling pathways i

Objective Apolipoprotein C1(APOC1)belongs to apolipoprotein C family is expressed primarily in the liver,and most has been found strongly association with lipid metabolism relative diseases.

会议

apolipoprotein C1 (APOC1)MAPK signalingcolorectal cancerproliferationinvasio

IL-6 secreted by cancer-associated fibroblasts promotes epithelial-mesenchymal transition and metast

Objective Gastric cancer,one of the most common primary malignant tumors,is the third leading cause of cancer death in worldwide with the highest estimated mortality rates in Eastern Asia1.

会议

cancer-associated fibroblastsinterleukin-6JAK/STAT3gastric cancer

Effect of Vismogib on the function of gastric Cancer cells through Hedgehog Signaling Pathway

Objective The aim of our study was to investigate the effect of HH signaling pathway inhibitor(Vismogib)on the function of gastric cancer cells by inhibiting HH signaling pathway in gastric cancer cel

会议

gastric cancerVismogibHedgehog pathway

The role of HSF1 in the metastasis and prognosis of gastric cancer

Objective Tumor metastasis and recurrence are the primary contributors to poor prognosis in patients with Gastric Cancer(GC).The epithelial-mesenchymal transition(EMT)of tumor cells is the predominant

会议

HSF1Gastric CancerInvasionMetastasisEMT

Huaier n-butanol Extract Suppresses Proliferation and Metastasis of Gastric Cancer by Inhibiting the

Objective Gastric cancer(GC)ranks 2nd among the cause of cancer-related mortality worldwide,and approximately 42%of all cases diagnosed each year worldwide are diagnosed in China.

会议

Gastric cancerHuaier n-butanol extractcell proliferationcell metastasis