Ursolic Acid(UA)is natural compound which has been shown to possess wide range of pharmacological activities including anti-inflammatory,anti-cancer,anti-oxidant and anti-microbial effects,but its bioavailability is limited by the poor water solubility.In the past few years,improve the efficacy of drug delivery,active targeted nanotechnology-based drug delivery systems are gaining considerable attention as they have the potential to improve bioavailability,minimize toxicity,and improve efficacy of anticancer treatment.