【摘 要】
：
Synthetic nucleic acid vectors have exhibited a great potential in cancer therapy compared with viral vectors[1].To achieve therapeutic effect,synthetic vectors must accomplish a series of tasks,inclu
【机 构】
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School of Pharmacy,Shanghai Jiao Tong University,Shanghai 200240,China
【出 处】
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Fourth Symposium on Innovative Polymers for Controlled Deliv
论文部分内容阅读
Synthetic nucleic acid vectors have exhibited a great potential in cancer therapy compared with viral vectors[1].To achieve therapeutic effect,synthetic vectors must accomplish a series of tasks,including wrapping nucleic acids tightly,having relative stability in the blood,preventing non-specific interactions,reaching targeted cells through the enhanced permeability and retention (EPR) effect,active targeting property of vector,and mediating cell entry and endosomal escape for release cargoes in a controlled manner[2].However,most synthetic vectors have not achieved the ideal systemic delivery of nucleic acids because of high chemical toxicity and low transfection efficiency.
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