【摘 要】
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Proteinuria is involved in the development of tubular lesions and in the progressive loss of renal function in chronic kidney diseases (CKDs) via uncertainmechanisms.Growing evidence suggests a pathog
【机 构】
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Nanjing Children's Hospital,affiliated with Nanjing Medical University
【出 处】
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中华医学会肾脏病学分会2014年学术年会
论文部分内容阅读
Proteinuria is involved in the development of tubular lesions and in the progressive loss of renal function in chronic kidney diseases (CKDs) via uncertainmechanisms.Growing evidence suggests a pathogenic role of mitochondrial dysfunction in CKDs.Therefore,the present study aims to define the roles of mitochondria in proteinuria-induced renal tubular injury and their underlying mechanisms.Employing the albumin-overload mouse model,we observed severe tubular structure damage and striking tubular cell apoptosis.Furthermore,the tubular epithelial cells displayed a loss of E-cadherin expression and gained expression of α-SMA and vimentin,indicating a cellular phenotypic alteration.Strikingly,these albumin overload-induced abnormalities were robustly blocked by a mitochondrial superoxide dismutase-2 mimic,MnTBAP.In agreement with these results,we observed a marked change in mitochondrial morphology accompanied by mitochondrial Cytochrome c release andmtDNA copy number reduction.
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