【摘 要】
：
Iridoid glycosides are the major component of Corni Fructus.The iridoid glycosides isolated from Corni Fructus(CIG)may act as an anti-oxidant,anti-inflammatory and anti-hyperglycemic agent.In this stu
【机 构】
：
Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemi
【出 处】
：
陕西省植物学会2018年学术研讨会
论文部分内容阅读
Iridoid glycosides are the major component of Corni Fructus.The iridoid glycosides isolated from Corni Fructus(CIG)may act as an anti-oxidant,anti-inflammatory and anti-hyperglycemic agent.In this study,we first investigated the hypoglycemic and hypolipidemic effects of CIG in a high-fat diet(HFD)and streptozotocin(STZ)-induced diabetic mice,And then,we further studied on underlying mechanism involving level of protein expression.The results showed that the ability of oral glucose tolerance was improved in the CIG group.Biochemical indices also revealed that CIG had a positive effect on hypolipidemic activity.Furthermore,CIG significantly enhanced the expression levels of INSR,PI3K,Akt/PKB and GLUT4 in skeletal muscle,which are critical regulators of insulin metabolism.
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