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  5. 老年抑郁症不同证候阶段外周血单胺类神经递质与甲状腺激素相关性研究

老年抑郁症不同证候阶段外周血单胺类神经递质与甲状腺激素相关性研究

来源 :世界中医药学会联合会第二届老年医学专业委员会换届会暨2015学术年会 | 被引量 : 0次 | 上传用户：lostsoul8888
【摘 要】
：
目的 探讨老年抑郁症患者不同证候阶段外周血甲状腺激素与神经递质变化及其相关性.方法 患者组203例,其中实证证候阶段(肝郁气滞)患者28例,虚实夹杂证候阶段(肝郁脾虚、肝郁痰阻)患者74例,虚证证候阶段(心脾两虚、心肾不交)患者101例,正常对照组50例,测定外周血血清总三碘甲状腺原氨酸(T3)、血清总甲状腺素(T4)、血清促甲状腺素(TSH)、五羟色胺(5-HT)、去甲肾上腺素(NE)及多巴胺(
【作 者】
：
程皓 李跃华 
【机 构】
：
北京宣武中医医院,100050 北京市西苑中医院,100091
【出 处】
：
世界中医药学会联合会第二届老年医学专业委员会换届会暨2015学术年会
【发表日期】
：
2015年3期
【关键词】
：
抑郁症 症候阶段 神经递质 甲状腺激素 
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　　目的 探讨老年抑郁症患者不同证候阶段外周血甲状腺激素与神经递质变化及其相关性.方法 患者组203例,其中实证证候阶段(肝郁气滞)患者28例,虚实夹杂证候阶段(肝郁脾虚、肝郁痰阻)患者74例,虚证证候阶段(心脾两虚、心肾不交)患者101例,正常对照组50例,测定外周血血清总三碘甲状腺原氨酸(T3)、血清总甲状腺素(T4)、血清促甲状腺素(TSH)、五羟色胺(5-HT)、去甲肾上腺素(NE)及多巴胺(DA)水平.结果 虚证证候阶段T3的降低及TSH的升高较对照组明显(P＜0.05).5-HT与TSH之间呈负相关(r=-0.89,P＜0.01)5-HT与T3之间呈正相关(r=-0.94,P＜0.01)结论 老年抑郁症患者不同证候阶段与单胺类神经递质及甲状腺激素功能密切相关.
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