Antibodies are important tools for investigating the proteome,but current methods for producing them have become a rate-limiting step in proteomic studies.A primary obstacle in most methods for generating antibodies is the requirement for at least microgram quantities of purified protein.A new technology genetic immunization for producing antibodies has been developed.Genetic immunization?based antibody production offers several advantages,including high throughput and high specificity.Moreover,antibodies produced from genetically immunized animals are more likely to recognize the native proteins.