目的:观察跑台运动训练和停训对去卵巢大鼠腰椎骨生物力学指标的影响。方法:60只成年雌性SD大鼠按体重分层后随机分为假手术组、去卵巢静止组和去卵巢运动组,每组20只。去卵巢运动组每周进行4次时间45 min、速度18 m/min、跑道倾角5°的跑台训练,持续训练14周时,将各组大鼠再随机分为两个亚组,即假手术16周(Sham-16)组和假手术32周(Sham-32)组、去卵巢16周(OVX-16)组和去卵巢32周(OVX-32)组及去卵巢运动组(EX)和停训组(D-EX)。分别在末次训练结束36~48小时内或停训16周时,采用万能电子试验机检测各组大鼠腰椎骨生物力学指标。结果:(1)训练结束时,OVX-16组大鼠腰椎最大载荷、破坏载荷、弹性模量、破坏挠度、最大应力、破坏应力和破坏应变均显著低于Sham-16组,而最大挠度和最大应变差异无统计学意义;EX组大鼠腰椎最大载荷、破坏载荷、弹性模量、最大应力和破坏应力均显著高于OVX-16组,而最大挠度、破坏挠度、最大应变和破坏应变差异无统计学意义。(2)停训结束时,OVX-32组大鼠腰椎最大载荷、破坏载荷、弹性模量、最大桡度、破坏挠度、最大应力、破坏应力和破坏应变显著低于Sham-32组,而最大应变差异无统计学意义;D-EX组大鼠腰椎破坏载荷、弹性模量和破坏应力显著低于OVX-32组,而最大载荷、最大挠度、破坏挠度、最大应力、最大应变和破坏应变差异无统计学意义。结论:中等强度跑台运动仅改善去卵巢大鼠腰椎部分骨生物力学指标,且停训后不能保持这些改善效应,部分指标变得更差。 Objective: To observe the effect of treadmill training and stop training on lumbar spine biomechanical parameters in ovariectomized rats. Methods: Sixty adult female SD rats were randomly divided into sham group, ovariectomized group and ovariectomized group with 20 rats in each group. The ovariectomized rats were trained four times per week for 45 minutes, at a speed of 18 m / min and runway inclination of 5 °. After continuous training for 14 weeks, the rats in each group were randomly divided into two subgroups: The Sham-16 and Sham-32 groups, the ovariectomized 16 weeks (OVX-16) group and the OVX-32 and ovariectomized groups (EX) And stop training group (D-EX). Respectively at the end of the last training 36 to 48 hours or stop training 16 weeks, using universal electronic testing machine to detect the lumbar spine biomechanical indicators of each group. Results: (1) At the end of training, the maximum load, breaking load, elastic modulus, breaking deflection, maximum stress, failure stress and failure strain of lumbar spine of OVX-16 group were significantly lower than those of Sham-16 group The maximum strain, lumbar spondylolisthesis, destructive load, elastic modulus, maximum stress and failure stress in EX group were significantly higher than those in OVX-16 group, while the maximum deflection, failure deflection, maximum strain and failure strain were significantly different No statistical significance. (2) At the end of stop training, the maximum load, the breaking load, the elastic modulus, the maximum radius, the breaking deflection, the maximum stress, the breaking stress and the breaking strain of lumbar spine of OVX-32 group were significantly lower than those of Sham-32 group There was no significant difference in strain between the two groups. The destructive load, elastic modulus and stress of lumbar spine in D-EX group were significantly lower than those in OVX-32 group, while the maximum load, maximum deflection, failure deflection, maximum stress, maximum strain and failure strain No statistical significance. Conclusion: The moderate intensity treadmill exercise only improves the biomechanical parameters of lumbar vertebrae in ovariectomized rats. After stopping training, these improving effects can not be maintained, and some of the indexes become worse.