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Oxide dispersion strengthened(ODS)ferritic steels are considered as the most promising candidate materials for future fission and fusion structural materials.The ODS-CLAM steel was fabricated by mechanical alloying(MA)and hot isostatic pressing(HIP).To investigate the effects of interface structure on the mechanical properties and irradiation resistance of ODS-CLAM steel,various interfacial structures between different oxide nano-particles such as YAlO3,Y2Ti2O7 and Y2Si2O7 and the matrix in ODS-CLAM steel were obtained by addition of different oxides and minor alloying elements.