鲫鱼PKZ Zα结构域翻转发夹d(GC)nT4(GC)n构象分析

来源 :中国水产学会鱼病学专业委员会2011年学术讨论会 | 被引量 : 0次 | 上传用户:tsy99
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  鲫鱼PKZ是最早报道的鱼类PKZ,为eIF2α激酶家族新成员,其N-端为Z-DNA结合域(Zα),C-端具有eIF2α激酶催化结构域。鲫鱼PKZ Zα与负超螺旋下的d(GC)n具有很高的亲和性。为进一步研究鲫鱼PKZ Zα的功能,我们首先利用圆二色谱(CD)检测了鲫鱼PKZ Zα翻转不同长度发夹DNA d(GC)nT4(GC)n的能力。
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