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目的 Intermittent hypoxia(IH),as the most important pathophysiologic characteristic of obstructive sleep apnea(OSA)and arecognized risk factor for cardiovascular disorders,may lead to proliferation of smooth muscle cells(SMCs)and then pulmonaryarterial remodeling through the RhoA/ROCK signaling pathway.In this preliminary study,an IH animal model was developed,andthe muscularization of small pulmonary arteries and RhoA/ROCK levels in these rats exposed to IH were studied.