Nanogenerators based on piezoelectric semiconductor nanostructures are very promising for the miniaturization of power packages and self-powering of nanosystems used in implantable bio-sensing, environmental monitoring, and personal electronics.New strategies for the dramatic enhancement of the power generation to commercialize the nanogenerators are indispensable for not only self-powered body-implantable nano/micro-systems, but also portable devices such as commercial LCDs, LEDs, etc with low operating power consumption.