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5. Study on the cell penetrating peptide targeting to brain(PTB)based on RVG29R9 and PTB modified lipos

Study on the cell penetrating peptide targeting to brain(PTB)based on RVG29R9 and PTB modified lipos

来源 :2016年中国药物制剂大会、中国药学会药剂专业委员会2016年学术年会、中国化学制药工业协会固体制剂专业委员会2016年 | 被引量 : 0次 | 上传用户：sellene

【摘 要】

：

It was reported that the conjugate compound of nona-arginine(R9)and 29 peptides from rabies virus glycoprotein(RVG),a substrate of N-acetylcholine receptor,had delivered siRNA into the brain tissue ef

【作 者】

：

HEI YU SUN DAN WANG GUILING XIE YING 

【机 构】

：

Department of Pharmaceutics,School of Pharmaceutical Science,Peking University,Beijing,China,100191

【出 处】

：

2016年中国药物制剂大会、中国药学会药剂专业委员会2016年学术年会、中国化学制药工业协会固体制剂专业委员会2016年

【发表日期】

：

2016年4期

【关键词】

：

Blood brain barrier Rabies Virus Glycoprotein Cell-penetrating peptides Liposome 

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论文部分内容阅读

　　It was reported that the conjugate compound of nona-arginine(R9)and 29 peptides from rabies virus glycoprotein(RVG),a substrate of N-acetylcholine receptor,had delivered siRNA into the brain tissue effectively.It demonstrated that the compound named as RVG29R9 had good ability to cross the blood brain barrier(BBB).

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