It is hard to realize structural and functional regeneration of critical osteochondral defects spontaneously by inherent self-healing ability without artificial interference.Cartilage regeneration based on traditional tissue engineering has been impeded on the path from laboratory bench to bedside.Evoking and supporting the self-healing and self-remolding process of cartilage regeneration simply by introducing a cartilage inductive scaffold would be a promising way to push forward the clinical application.[1] A proper biomaterial-based scaffold plays an essential role in this process.Scaffolds with cell-penetration facilitating structure and chondrogenesis inductive bioactivity would promote the in situ inductive regeneration of osteochondral defects.Radially oriented pores could be easily granted to scaffolds based on poly(lactic-co-glycolic acid)or hyaluronic acid through thermally induced phase separation.[2] In vitro evaluation proved less special obstacle for cell penetration,while in vivo implantation confirmed more obvious simultaneously regenerated cartilage and subchondral bone in poly(lactic-co-glycolic acid)scaffolds with oriented rather than random porous structure,even though cartilage specific extracellular matrices deposition is not as high as native cartilage.Bioactive hyaluronic acid could function as a chondrogenesis inductor,leading to chondrogenetic of bone marrow stem cells as well as increase of cartilage specific extracellular matrices deposition.[3] In vitro culture of bone marrow stem cells within scaffolds based on hyaluronic acid proved spontaneously cells aggregation.Radially oriented pores and bioactivity of hyaluronic acid lead to improved full regeneration of cartilage and subchondral bone with great integration and higher deposition of matrices.