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  5. Insight into Conformational Change for 14-3-3σ Protein by Molecular Dynamics Simulation

Insight into Conformational Change for 14-3-3σ Protein by Molecular Dynamics Simulation

来源 :第六届全国生物信息学与系统生物学学术大会暨国际生物信息学前沿研讨会 | 被引量 : 0次 | 上传用户：puccacat
【摘 要】
：
Background: 14-3-3σ is a member of a highly conserved family of 14-3-3 proteins that has a double-edged sword role in human cancers.The 14-3-3 proteins can bind several hundred diverse target proteins
【作 者】
：
扈国栋 刘倩君 李海彦 梁涛 王吉华 
【机 构】
：
山东省功能大分子生物物理重点实验室,物理与电子信息学院,德州学院,德州253023
【出 处】
：
第六届全国生物信息学与系统生物学学术大会暨国际生物信息学前沿研讨会
【发表日期】
：
2014年4期
【关键词】
：
conformational change 14-3-3σ protein molecular dynamics simulation 
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　　Background: 14-3-3σ is a member of a highly conserved family of 14-3-3 proteins that has a double-edged sword role in human cancers.The 14-3-3 proteins can bind several hundred diverse target proteins.Former reports have indicated that the 14-3-3 protein may be in an open or closed state.
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