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  5. Modular construction of synthetic circuits using TALE transcriptional repressors in mammalian cells

Modular construction of synthetic circuits using TALE transcriptional repressors in mammalian cells

来源 :第六届全国生物信息学与系统生物学学术大会暨国际生物信息学前沿研讨会 | 被引量 : 0次 | 上传用户：Mciael
【摘 要】
：
Background: An important goal of synthetic biology is the rational design and predictable implementation of synthetic gene circuits using standardized and interchangeable parts.However, engineering of
【作 者】
：
李寅青 蒋云 陈赫 廖微曦 李智华 Ron Weiss 谢震 
【机 构】
：
电子工程和计算机科学系,麻省理工学院,艾姆斯街40号,剑桥,马赛诸塞州,02142,美国 生物信息
【出 处】
：
第六届全国生物信息学与系统生物学学术大会暨国际生物信息学前沿研讨会
【发表日期】
：
2014年4期
【关键词】
：
synthetic gene circuit transcription activator-like effector repressors represso 
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　　Background: An important goal of synthetic biology is the rational design and predictable implementation of synthetic gene circuits using standardized and interchangeable parts.However, engineering of complex circuits in mammalian cells is currently limited by the availability of well-characterized and orthogonal transcriptional repressors.
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