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多组分反应，是指三种或更多种不同原料直接形成产物，具有无需分离中间产物、操作简单等优点。多组分反应作为一种高效的合成方法，正受到化学家们越来越多的关注。[1]同时，嘌呤类化合物具有很好的抗肿瘤、抗艾滋等药物活性，也得到了广泛的关注和研究。
通过三组分串联Heck-Negishi偶联反应修饰嘌呤
【摘 要】
：
多组分反应，是指三种或更多种不同原料直接形成产物，具有无需分离中间产物、操作简单等优点。多组分反应作为一种高效的合成方法，正受到化学家们越来越多的关注。[1]同时，嘌呤类化合物具有很好的抗肿瘤、抗艾滋等药物活性，也得到了广泛的关注和研究。
【机 构】
：
河南师范大学化学化工学院 新乡 453007 河南科技学院 新乡 453003
【出 处】
：
河南省化学会2014年学术年会
【发表日期】
：
2014年6期
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嘌呤-8-酮类化合物具有很好的生物活性，[1]比如嘌呤-8-酮A 具有抗焦虑、抗抑郁的作用；嘌呤-8-酮B 与C 是很好的干扰素诱导剂；嘌呤-8-酮D 具有很好的抗氧化性。因此，嘌呤-8-酮类化合物的合成备受化学家们的关注。
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