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  5. Protective effects of polygalasaponin F on PC12 cells injuried by serum deprivation, oxidative stres

Protective effects of polygalasaponin F on PC12 cells injuried by serum deprivation, oxidative stres

来源 :International Conference for Physiological Sciences 2012(201 | 被引量 : 0次 | 上传用户：freeman_1982
【摘 要】
：
Aim To study the effects of Polygalasaponin F (PGSF) on PC12 cells.Methods The viability of cells was determined by MTT assay.Cell apoptosis was assessed by propidium iodide/Hoechst 33258 staining and
【作 者】
：
Rui-li Shi Jin-feng Hu Nai-hong Chen 
【机 构】
：
Department of Physiology,Baotou Medical College,Baotou,China
【出 处】
：
International Conference for Physiological Sciences 2012(201
【发表日期】
：
2012年8期
【关键词】
：
polygalasaponin F serum deprivation oxidative stress OGD/R 
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　　Aim To study the effects of Polygalasaponin F (PGSF) on PC12 cells.Methods The viability of cells was determined by MTT assay.Cell apoptosis was assessed by propidium iodide/Hoechst 33258 staining and flow cytometry assay.The expression of Bcl-2 and Bax proteins were detected by Western blot.Results PGSF elevated cell viability markedly.In oxygen-glucose deprivation and reperfusion model (OGD/R), it improved the morphology of cells, attenuated apoptosis of cells and prevented the up-regulation of Bax as well as the down-regulation of Bcl-2.Conclusion PGSF could protect PC12 cells against injury induced by serum deprivation,oxidative stress or OGD/R.
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