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目的 :观察 2型糖尿病合并肾病和无肾病患者骨密度 (BMD)变化。方法 :应用双能X线吸收仪 (DEXA)测定 93例 2型糖尿病患者腰L1～L4 和髋关节部位的骨密度 ,根据 2 4h尿白蛋白排泄量将 2型糖尿病分为肾病组 (2 4h尿白蛋白 >30mg)和无肾病组 (2 4h尿白蛋白 <30mg) ,并与正常对照组比较。结果 :2型糖尿病无肾病组女性各部位BDM与对照组比较差异无显著性 (P >0 .0 5 ) ,男性L2 、股骨、股骨颈BMD高于对照组 (P <0 .0 5 )。糖尿病肾病组女性股骨、股骨颈、男性各部位BMD较无肾病组降低 ,但无统计学差异 (P >0 .0 5 )。结论 :2型糖尿病患者无肾损害时骨密度可正常或增高 ,合并糖尿病肾病时骨密度有下降趋势。
Objective: To observe the changes of bone mineral density (BMD) in patients with type 2 diabetes mellitus and without nephropathy. Methods: Bone mineral density (BMD) in L1 ~ L4 and hip joints of 93 patients with type 2 diabetes mellitus were measured by dual energy X-ray absorptiometry (DEXA). According to 24 h urinary albumin excretion, type 2 diabetes was divided into two groups: Urinary albumin> 30mg) and no nephropathy group (24h urine albumin <30mg), and compared with the normal control group. Results: There was no significant difference in BDM between the two groups (P> 0.05). The BMD of L2, femur and femoral neck were higher in the non-nephropathy group than in the control group (P <0.05). BMD in femoral neck, femoral neck and male in diabetic nephropathy group was lower than that in non-nephropathy group, but there was no significant difference (P> 0.05). Conclusion: Patients with type 2 diabetes may have normal or increased bone mineral density without renal impairment, and bone mineral density may decline with diabetic nephropathy.