【摘 要】
：
Recombinant adeno-associated virus(rAAV)vectors are extremely promising gene therapy vectors,which has been widely used in the treatments of cancer or other genetic diseases,owing to its non-pathogeni
【机 构】
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Engineering Research Center of Molecular Medicine,Ministry of Education and Institutes of Molecular
【出 处】
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中国微米纳米技术学会纳米科学技术分会第四届年会暨2016国际纳米生物与医学学术会议
论文部分内容阅读
Recombinant adeno-associated virus(rAAV)vectors are extremely promising gene therapy vectors,which has been widely used in the treatments of cancer or other genetic diseases,owing to its non-pathogenic,low immune response,potential to integrate site-specifically,persistent and stable gene expression.However,because it was easy to be neutralized in serum and non-selection to the site-target,rAAV was limited in clinical applications.Macromolecules were studied to modified rAAV to overcome those problems though ploymer encapsulation,polyelectrolyte adsorption or polymer conjugating to virus capsid.
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