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Botulinum neurotoxins(BoNTs)are known as the most toxic natural substances.Synaptic vesicle protein 2(SV2)has been proposed to be a protein receptor for BoNT/A.Recently,two short peptides(BoNT/A-A2 and SV2CA3)were designed to inhibit complex formation between the BoNT/A receptor-binding domain(BoNT/A-RBD)and the synaptic vesicle protein 2C luminal domain(SV2C-LD).