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  5. Novel Fluorescent Probe for the Sensitive Detection of b-Amyloid Deposits

Novel Fluorescent Probe for the Sensitive Detection of b-Amyloid Deposits

来源 :2015年全国药物化学学术会议暨第五届中英药物化学学术会议 | 被引量 : 0次 | 上传用户：silencegrrr
【摘 要】
：
Senile Aβ plaques have been widely found in post-mortem brains of Alzheimers disease(AD)patients and are viewed as one of the principal hallmarks of the disease[1].A deposits are therefore thought to
【作 者】
：
Wenming Ren Mingming Xu Xin Li Haiyan Zhang Youhong Hu 
【机 构】
：
State Key Laborarory of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Scienc
【出 处】
：
2015年全国药物化学学术会议暨第五届中英药物化学学术会议
【发表日期】
：
2015年3期
【关键词】
：
A plaque fluorescent probe donor-bridge-acceptor system BODIPY turned-on 
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　　Senile Aβ plaques have been widely found in post-mortem brains of Alzheimers disease(AD)patients and are viewed as one of the principal hallmarks of the disease[1].A deposits are therefore thought to be a good diagnostic and predictive biomarker for this disease [2,3,4].BODIPY-based off-on probe 1 was discovered as a novel probe for the specific staining of A plaques.
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