The physical properties, such as shape, size,mechanical properties, surface texture and compartmentalization, profoundly impact the function of a nano biomaterial and thus raises important questions for the design of its next generation.Often, electrospun nanofibers of some typical pharmaceutical polymers (such as cellulose acetate, Eudragit series and zein) exhibit a flat morphology, which is undesired for providing sustained drug release profiles because the flat morphology aggravates the initial burst release effect and results in a shorter time sustained release.